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Spine Scoping Review

Objective:  The purpose of this scoping review is to chart the characteristics of the epidemiological literature that report associations between spine-related pain and pathologies (SPPs) and common non-spinal health conditions (NSHCs), such as cardiovascular diseases, cancers, diabetes, and respiratory disorders, are leading causes of mortality, disability, disability-adjusted life years and morbidity. Our aim is to provide a comprehensive overview of the literature that reports associations between SPPs and NSHCs, to describe the research knowledge base, identify gaps, and report evidence that may inform future research and practices.


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Association between spinal and non-spinal health conditions reported in epidemiological studies: a scoping review protocol

Introduction The increasing prevalence of coexisting health conditions poses a challenge to healthcare providers and healthcare systems. Spinal pain (eg, neck and back pain) and spinal pathologies (eg, osteoporotic fractures and degenerative spinal disease) exist concurrently with other non-spinal health conditions (NSHC). However, the scope of what associations may exist among these co-occurring conditions is unclear. Therefore, this scoping review aims to map the epidemiological literature that reports associations between spine-related pain and pathologies (SPPs) and NSHCs.

Methods and analysis This scoping review will follow the JBI protocol and Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews. We will systematically search the literature using key words and MeSH terms for SPPs and NSHCs. Terminology/vocabulary for NSHCs will include those for communicable and non-communicable diseases as reported by WHO Global Burden of Disease reports. Five databases will be searched from inception: MEDLINE, EMBASE, APA PsycInfo, Scopus and Web of Science Core Collection. Papers published in English, in peer-reviewed journals, including measures of association between SPPs and NSHCs and using observational epidemiologic study designs will be included. Excluded will be studies of cadaveric, animal or health behaviours; studies with no measures of association and non-observational epidemiologic studies. Results will include the number of studies, the studies that have evaluated the measures of association and the frequency of the studied associations between SPPs and NSHCs. Results will be reported in tables and diagrams. Themes of comorbidities will be synthesised into a descriptive report.

Ethics and dissemination This scoping review was deemed exempt from ethics review. This review will provide a comprehensive overview of the literature that reports associations between SPPs and NSHCs to inform future research initiatives and practices. Results will be disseminated through publication in peer-reviewed journals and research conferences.

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Information and Training

Authorship Team

The authorship team represents a diverse range of regions, professions, and expertise.

AuthorTeam 4-20-2024.png

Additional Information

Past drafts and other information will be located here. 

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